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On/Offcall: What Is a World Model in AI? AMI Labs' Yann LeCun and CEO Alex LeBrun Explain

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On/Offcall is the weekly dose of information and inspiration that every physician needs.

🚨 Two absolute legends in AI…sitting together for the first time…to reveal the boldest new AI model set to take over the world…

We’re talking about the one and only Yann LeCun, the former Meta Chief AI Scientist and one of the world’s foremost pioneers of deep learning, and Alex LeBrun, the prolific AI entrepreneur, CEO of Nabla, one of the leading ambient AI technology companies in healthcare, and CEO of AMI Labs.

For the first time ever, Offcall co-founder and EM physician Graham Walker, MD took How I Doctor on the road, traveling to Nabla’s recent Accelerate conference to host a rare sit down with Yann and Alex to discuss their newest company, AMI Labs, and what they hope to accomplish in healthcare.

👀 If you thought LLMs were the future of AI in medicine… think again.

After years of building Nabla into one of the leading ambient AI companies for clinicians, Alex recently teamed up with Yann to pursue a lofty goal they hope will also have a big impact on healthcare: building world models that reason and show judgment just like humans. 🤯

Together, they cover:

🧠 What “world models” are and how they could augment clinical judgment in healthcare
📉 The current shortcomings of LLMs like ChatGPT in precision-fields like medicine
⚙️ Lessons learned from building Nabla alongside clinicians
🌍 What it means to build a new kind of AI that supports judgment, not replaces it
🩺 Which specialties are most at risk of being upended by AI world models
And more!

Don’t look now, but we have a hunch this conversation will be referenced by the entire medical AI community for years to come … Get your popcorn ready for a must-watch conversation for anyone trying to understand how AI will transform medicine. 🍿

🎧 Listen to the full episode here

Thank you to our amazing sponsor: Sevaro, the physician-led telestroke and neurology company delivering rapid, reliable virtual neuro coverage.

Know someone who would benefit from joining us? Help us grow our tent by forwarding this newsletter to your physician colleagues and subscribing here.

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Note: As an exclusive benefit for Offcall's members, Sophie is offering a special discount for her organization’s upcoming CME-accredited Clinician (H)Arts and Wellness Conference in Santa Fe in August 2026. Learn more details here and if you enter OFFCALL100 when you register, you'll get $100 off of the conference registration!

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1. Owais, what do you think the public most misunderstands about being a physician in 2026? A common misconception is that everyday physicians are simply relying on what we learned years ago. In reality, medicine is constantly evolving, and so are we. Physicians are required to engage in ongoing continuing medical education, have cases reviewed, and participate in hospital committees that shape clinical guidance, protocols, and standards of care. Many of us are also deeply involved in medical societies, contributing to policy, advocacy, and the direction of our specialties. Being a physician in 2026 isn’t just about applying existing knowledge, it’s about actively helping shape how medicine changes, improves, and adapts in real time.

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Offcall Team
Written by Offcall Team

Offcall Team is the official Offcall account.

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